Regulation effect and mechanism of Sheng-Hua-Tang on female reproductive system: from experimental transcriptomic analysis to clinical applications

Sheng-Hua-Tang (SHT) is commonly used to treat female illnesses, especially postpartum conditioning. However, its effects and mechanisms on female reproductive system remain unclear. The aim of the present study was to investigate the effect of SHT on female brain-ovary-uterus axis from bench to clinic. Mice were administrated SHT (200 mg/kg) orally for seven consecutive days. Brain, ovary, and uterus tissues were then collected for microarray analysis.

生化汤（Sheng-Hua-Tang, SHT）是临床常用的妇科治疗方剂，尤其多用于产后调理。然而其对女性生殖系统的作用及分子机制尚未明确。本研究旨在探究生化汤对女性脑-卵巢-子宫轴的影响，研究覆盖从基础实验到临床转化的全链条。实验小鼠连续7天经口灌胃给予200 mg/kg的生化汤，随后采集其脑、卵巢及子宫组织开展基因芯片分析。