Comparative analysis of transcriptional profiles of adult Schistosoma japonicum from different laboratory animals and the natural host, water buffalo

Although numerous researches on schistosomiasis japonica have been performed using laboratory animal models, the comparison of gene expression profiles of S. japonicum from the different laboratory animals and natural hosts is still a gap. We systematically compared the gene expression profiles of schistosomes from different laboratory animals and water buffaloes. The findings of this study provide the basis for schistosomiasis research in different mammalian hosts at transcriptional level and valuable resource for the screening of anti-schistosomal intervention targets. Three biological replicates of adult male and female worms from BALB/c mice, C57BL/6 mice, New Zealand white rabbits and water buffaloes were analyzed.

尽管目前已有诸多采用实验动物模型开展的日本血吸虫病（schistosomiasis japonica）研究，但针对不同实验动物与自然宿主来源的日本血吸虫（Schistosoma japonicum）基因表达谱的比较研究仍存在空白。本研究系统比较了不同实验动物及水牛来源的血吸虫基因表达谱。本研究结果可为不同哺乳类宿主的血吸虫病转录水平研究提供理论基础，同时为抗血吸虫病干预靶点的筛选提供宝贵资源。本研究对来自BALB/c小鼠（BALB/c mice）、C57BL/6小鼠（C57BL/6 mice）、新西兰白兔（New Zealand white rabbits）及水牛的成年雌雄血吸虫成虫各3个生物学重复样本进行了分析。