DNA methylation profiles of human blood samples from older Tsimane, Caucasians, and Hispanics

Human DNA methylation Beadchip v1.2 was used to profile n=310 whole blood samples. The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of different ethnic groups. Here we focus on subjects older than 35. Groups include Tsimane Indians, Hispanics, and Caucasian samples. To measure DNA methylation age, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10.1186/gb-2013-14-10-r115 PMID: 24138928. We analyzed whole blood samples from 235 Caucasians, 38 Hispanics, and 37 Tsimane Indians.

本研究采用人类DNA甲基化微珠芯片v1.2（Human DNA methylation Beadchip v1.2）对310份全血样本进行甲基化谱分析。本研究的核心目标为测定不同种族人群的表观遗传年龄（epigenetic age，亦称为DNA甲基化年龄）。本次分析聚焦于35岁以上的受试者，受试人群涵盖齐曼印第安人、西班牙裔及高加索裔样本。为测定DNA甲基化年龄，我们采用了Horvath S于2013年在《DNA methylation age of human tissues and cell types》一文中所描述的表观遗传时钟软件，该文献发表于*Genome Biology* 2013年，卷14，论文编号R115，DOI: 10.1186/gb-2013-14-10-r115，PubMed编号（PMID）: 24138928。本次分析共纳入235名高加索裔、38名西班牙裔及37名齐曼印第安人的全血样本。