Asymmetric Co(II)-Catalyzed Cyclopropanation with Succinimidyl Diazoacetate: General Synthesis of Chiral Cyclopropyl Carboxamides

[Co(P1)] is an effective catalyst for asymmetric cyclopropanation with succinimidyl diazoacetate. The Co(II)-catalyzed reaction is suitable for various olefins, providing the desired cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantioselectivity. The resulting enantioenriched cyclopropane succinimidyl esters can serve as convenient synthons for the general synthesis of optically active cyclopropyl carboxamides.

[Co(P1)]是催化以重氮乙酸琥珀酰亚胺酯 (succinimidyl diazoacetate) 为底物的不对称环丙烷化反应的高效催化剂。该二价钴(Co(II))催化的反应适用于多种烯烃，能够以高收率、优异的非对映选择性与对映选择性得到目标环丙烷羧酸琥珀酰亚胺酯 (cyclopropane succinimidyl esters)。所得对映富集的环丙烷羧酸琥珀酰亚胺酯可作为便捷合成子，用于光学活性环丙基甲酰胺 (optically active cyclopropyl carboxamides) 的通用合成。