HCA Placenta Adult Vento RNA

The Human Cell Atlas initiative is an ambitious global research effort which aims to describe every cell in the human body across all developmental stages to generate a reference map to accelerate progress in science and medicine particularly relating to human development and disease. The initiative is led by investigators based at the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard and funding support from the Wellcome and NIH. This specific project will assess human development. We aim to interrogate the cellular composition and molecular regulators underpinning development and maturation through single cell RNA-sequencing/spatial transcriptomics and computational algorithms to predict cellular developmental trajectories and cell-cell interactions. We will subsequent validate these findings in situ using allied imaging technologies e.g. immunohistochemistry and RNAscope and in vitro culture of human intestinal organoids (HIOs).

This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/EGA study EGAS00001004069

人类细胞图谱（Human Cell Atlas）计划是一项雄心勃勃的全球性研究项目，旨在全面刻画人体在所有发育阶段的每一类细胞，构建参考图谱以加速科学与医学领域的研究进展，尤其是在人类发育与疾病相关方向。该计划由惠康桑格研究所（Wellcome Sanger Institute）与麻省理工学院-哈佛大学布罗德研究所（Broad Institute of MIT and Harvard）的研究人员主导，并获得惠康基金会（Wellcome）与美国国立卫生研究院（NIH）的经费支持。本专项项目将聚焦人类发育研究，我们旨在通过单细胞RNA测序（single cell RNA-sequencing）/空间转录组学（spatial transcriptomics）与计算算法，解析支撑发育与成熟过程的细胞组成及分子调控机制，进而预测细胞发育轨迹与细胞间相互作用。后续我们将通过相关成像技术（如免疫组织化学与RNAscope原位杂交技术）以及人类肠道类器官（HIOs）的体外培养模型，对上述研究发现进行原位验证。

本数据集属于预发布数据。若需了解惠康桑格研究所共享的预发布数据的规范使用方式（包括任何出版暂缓相关细则），请访问http://www.sanger.ac.uk/datasharing/，对应的EGA研究编号为EGAS00001004069。