KNOTTIN

The KNOTTIN database provides standardized information on the small disulfide-rich proteins with a knotted topology called knottins or inhibitor cystine knots. Static pages present the essential historical or recent results about knottin discoveries, sequences, structures, syntheses, folding, functions, applications and bibliography. New tools, KNOTER3D and KNOTER1D, are provided to determine or predict if a user query (3D structure or sequence) is a knottin. These tools are now used to automate the database update. All knottin structures and sequences in the database are now standardized according to the knottin nomenclature based on loop lengths between knotted cysteines, and to the knottin numbering scheme.

KNOTTIN数据库提供了针对具有打结拓扑结构的富含二硫键的小型蛋白质的标准化信息，此类蛋白质被称为结蛋白（knottins）或抑制剂胱氨酸结（inhibitor cystine knots）。该数据库的静态页面展示了结蛋白领域的重要历史与最新研究成果，涵盖结蛋白的发现、序列、结构、合成、折叠、功能、应用及参考文献目录。该数据库提供了两款全新工具——KNOTER3D与KNOTER1D，可用于判定或预测用户提交的查询对象（三维结构或序列）是否属于结蛋白。目前这两款工具已被用于实现数据库更新的自动化流程。当前数据库内收录的所有结蛋白结构与序列，均已依据基于打结半胱氨酸间环长度的结蛋白命名规则，以及结蛋白编号体系完成标准化处理。