eMERGE III: CCHMC - eMERGE Cohorts - Phase IIIA

This submission includes genotyping or sequencing data from separate cohorts, each is described in separate paragraphs below. Extreme early onset obesity. Obesity is a serious epidemic condition and on the rise in the United States. Today, nearly one out of three children is overweight or obese in this country. According to the Center for Disease Control, 35.7% of American adults and 17% of American children are obese. The medical costs associated with obesity are estimated to be in the billions. Without a doubt, interplay of additive genetic effects and common environmental effects influence this complex disease. However, despite being exposed to so-called "obesogenic environment", a large proportion of the population remains of normal weight. These observations suggest that innate, non-environmental, factors make some individuals more susceptible to obesity providing support for biological mechanisms, and thus genetic factors, to underlie the individual... (for more see dbGaP study page.)

本提交数据包含来自独立队列的基因分型（genotyping）或测序（sequencing）数据，各队列的详细信息将在下文各段落中逐一说明。本研究聚焦极端早发性肥胖。肥胖是一种严重的流行性疾病，且在美国呈持续上升态势。当前美国近三分之一的儿童存在超重或肥胖问题。据美国疾病控制与预防中心（Center for Disease Control）统计，美国成年人群肥胖率达35.7%，儿童肥胖率为17%。与肥胖相关的医疗总成本估计高达数十亿美金。毋庸置疑，加性遗传效应与常见环境效应的交互作用会影响这一复杂疾病的发生发展。然而，尽管大量人群暴露于所谓的"obesogenic environment"，仍有相当比例的个体维持正常体重。上述观察结果提示，先天非环境因素会使部分个体更易罹患肥胖，这为肥胖发生的生物学机制（进而为遗传因素）提供了支持依据……（更多详情请参见dbGaP研究页面。）