Supplementary tables: Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data

<b>These are peer-reviewed supplementary tables for the article '</b><b>Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data</b><b>' published in the</b><b> </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b><br><b>Supplementary Table 1:</b> ICD-10-CM Codes for GI Manifestations<b>Supplementary Table 2:</b> CPT Codes for MECP2 Genetic Testing<b>Supplementary Table 3:</b> ICD-10-CM Codes for Quan-Charlson Comorbidity Index<b>Supplementary Table 4:</b> ICD-10-CM Codes for Differential Diagnosis of RTTAim: Patients with Rett syndrome (RTT) experience gastrointestinal (GI) manifestations. This study aimed to describe the prevalence of GI manifestations and the associated medical costs in patients with RTT in the USA. Patients &amp; Methods: The study combined an insurance claims database analysis with a survey of 100 physicians experienced in RTT management. Results: GI manifestations affected 43.0% of 5940 patients, with increased prevalence in pediatric patients (45.6%) relative to adult patients (40.2%). Annualized mean medical cost of managing GI manifestations was $4473. Only 5.9–8.2% of neurologists and pediatricians ranked GI symptom management among the five most important treatment goals. Conclusion: Patients with RTT experience a high burden of GI manifestations, which translate to considerable medical costs. Importantly, the prevalence of GI manifestations was likely underestimated in this study, as only those symptoms which resulted in a healthcare encounter were captured.<br>

本数据集为发表于《Journal of Comparative Effectiveness Research》的论文《Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data》（《雷特综合征儿童与成人患者的胃肠道表现：美国理赔数据与医师调查数据分析》）的同行评议补充表格。
- 补充表1：胃肠道表现的国际疾病分类第十版临床修改版（ICD-10-CM）编码
- 补充表2：MECP2基因检测的当前操作术语编码（CPT）
- 补充表3：全量-查尔森合并症指数的ICD-10-CM编码
- 补充表4：雷特综合征（Rett syndrome, RTT）鉴别诊断的ICD-10-CM编码

#### 研究概况
研究目的：雷特综合征（RTT）患者常出现胃肠道（GI）表现。本研究旨在描述美国雷特综合征患者的胃肠道表现患病率及其相关医疗成本。
研究对象与方法：本研究结合保险理赔数据库分析与对100名具备雷特综合征诊疗经验的医师开展的调查。
研究结果：胃肠道表现累及5940例患者中的43.0%，儿童患者患病率（45.6%）高于成人患者（40.2%）。管理胃肠道表现的年平均医疗成本为4473美元。仅有5.9%~8.2%的神经科医师与儿科医师将胃肠道症状管理列为五大核心治疗目标之一。
研究结论：雷特综合征患者面临沉重的胃肠道表现负担，并产生了可观的医疗成本。值得注意的是，本研究中胃肠道表现的患病率或存在低估，因仅统计了引发就医行为的相关症状。