Synthesis and Characterization of Axially Chiral Imidazoisoquinolin-2-ylidene Silver and Gold Complexes

The selective Suzuki cross-coupling
of 1,3-dichloroisoquinoline
with 2-substituted 1-naphthylboronic acids/esters followed by construction
of the imidazo­[1,5-b]­isoquinoline ring and alkylation
constitutes a straightforward route to imidazolium salts fused into
an axially chiral biaryl skeleton. Metalation of these azolium salts
afforded the corresponding NHC silver complexes, which were used as
carbene transfer agents for the synthesis of Au­(I) derivatives.

以1,3-二氯异喹啉与2-取代-1-萘基硼酸/硼酸酯的选择性铃木交叉偶联反应为起始步骤，经咪唑并[1,5-b]异喹啉环构建与烷基化反应，可便捷得到融合于轴手性联芳骨架的咪唑鎓盐。对该类咪唑鎓盐进行金属化反应，可获得对应的N-杂环卡宾（N-Heterocyclic Carbene, NHC）银配合物，此类配合物可用作卡宾转移试剂，用于金(I)衍生物的合成。