Gene expression profiling of advanced murine K-RasG12V lung adenocarcinomas

We aimed to analyze the transcriptional profile of full-blown murine lung adenocarcinomas driven by K-RasG12V oncogene. We used a GEM model of lung adenocarcinoma driven by a resident K-RasG12V oncogene. On average, tumors were collected 10 months after Adeno-CRE infection.

本研究旨在分析由K-RasG12V癌基因驱动的进展期小鼠肺腺癌的转录谱。本研究采用了由内源性K-RasG12V癌基因驱动的肺腺癌基因工程小鼠模型（Genetically Engineered Mouse model，GEM）。平均而言，研究人员在腺病毒-CRE（Adeno-CRE）感染后10个月收集肿瘤样本。