Methylation data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases and controls

Methylation profiling can reveal patterns of hypermethlation and hypomethylation associated with distinct biologic subtypes of acute lymphoblastic leukemia (ALL). We performed methylation profiling of Down syndrome ALL cases and controls to identify unique biologic features of this ALL subgroup. Ficoll-enriched, cryopreserved bone marrow aspirate samples were obtained from patients with B-precursor ALL at diagnosis and in remission

甲基化谱分析（Methylation profiling）可揭示与急性淋巴细胞白血病（ALL）不同生物学亚型相关的高甲基化与低甲基化模式。本研究针对唐氏综合征（Down syndrome）相关ALL病例及对照样本开展甲基化谱分析，以鉴定该ALL亚组独有的生物学特征。我们从诊断时及缓解期的前体B细胞急性淋巴细胞白血病患者处获取经聚蔗糖（Ficoll）富集的冻存骨髓穿刺样本。