Practical Synthesis of P-Stereogenic Diphosphacrowns

P-Stereogenic 18-diphosphacrown-6 derivatives containing a chiral bisphosphine unit were synthesized. This is the first practical method for the synthesis of optically pure diphosphacrowns. The diphosphacrowns have the structure of a chiral figure “8” with chiral heteroatoms that interact directly with guest ions and molecules. Pd(II) and Pt(II) complexes with the P-stereogenic diphosphacrowns were also synthesized and characterized.本研究合成了一类带有手性双膦单元的P-手性18-二磷杂冠-6衍生物。这是首例合成光学纯二磷杂冠醚的实用方法。该类二磷杂冠醚具有手性“8”字形结构，其手性杂原子可直接与客体离子及分子发生相互作用。此外，本研究还合成并表征了以该P-手性二磷杂冠醚为配体的钯(II)与铂(II)配合物。