Global Burden of Disease Study 2021 (GBD 2021) Sickle Cell Disease Birth Incidence, Prevalence, and Mortality 2000-2021

Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this dataset provides a global assessment of sickle cell disease (SCD) birth incidence, prevalence and mortality burden by age and sex for 204 countries and territories from 2000 to 2021. It includes estimates for three distinct genotype-specific SCD models: homozygous SCD and severe sickle cell/beta thalassaemia (SS and Sβ°), sickle cell-hemoglobin C disease (SC), and “mild” sickle cell/beta thalassaemia (Sβ+). The three model estimates were summed into estimates for “total SCD mortality.” The latter can be compared against the estimates provided for the GBD cause "Sickle cell disorders," both of which are also included in the dataset. Refer to the related publication for information on modeling methods and analysis.

本数据集系2021年全球疾病、伤害和风险因素负担研究（Global Burden of Diseases, Injuries, and Risk Factors Study, GBD）的成果之一，针对2000年至2021年的204个国家和地区，按年龄与性别维度，对镰状细胞病（sickle cell disease, SCD）的出生发病率、患病率及死亡负担开展了全球评估。数据集涵盖三类基于不同基因型的镰状细胞病模型估算值：纯合子镰状细胞病与重型镰状细胞/β地中海贫血（SS型及Sβ°型）、镰状细胞-血红蛋白C病（SC型），以及“轻型”镰状细胞/β地中海贫血（Sβ+型）。将上述三类模型的估算值汇总后，可得到“镰状细胞病总死亡负担”的估算结果。该结果可与GBD疾病分类中“镰状细胞病类”条目下的估算值进行对比，两类数据均已包含在本数据集内。有关建模方法与分析细节，请参阅相关学术出版物。

搜集汇总

背景与挑战

背景概述

该数据集是GBD 2021研究的一部分，提供了2000年至2021年全球204个国家和地区镰状细胞病（SCD）的出生发病率、患病率和死亡率评估，包括三种基因型特异性模型的详细估计。数据集特别关注SCD的全球疾病负担分析，并整合了总死亡率估计，可用于比较GBD原因中的'Sickle cell disorders'数据。