Loa loa Raw sequence reads. Loa loa

The collective burden of the common helminth diseases – which range from the dramatic sequelae of elephantiasis and blindness to the more subtle but widespread effects on child development, pregnancy, and productivity – rivals that of the main high-mortality conditions such as HIV/AIDS or malaria. The W.H.O. estimates 2.9 billion people are infected and morbidity from helminthes is substantial and rivals diabetes and lung cancer in worldwide DALY measurements. Despite some advances in drug availability and public health infrastructure, most helminth diseases have remained intractable problems.This study, involving L. loa and other nematodes, will provide the resources needed to create a comprehensive map of genetic diversity in helminth parasites, so that in the long run, the molecular profiling of human helminthiasis will be improved and the spread of resistance can be monitored and managed.

常见蠕虫病（helminth diseases）的整体疾病负担覆盖广泛，既包括象皮肿、失明这类严重后遗症，也包括对儿童发育、妊娠与生产力造成的隐匿却普遍的影响，其规模可与艾滋病（HIV/AIDS）、疟疾等主要高致死性疾病的疾病负担相媲美。世界卫生组织（World Health Organization，W.H.O.）估计，全球共有29亿人感染蠕虫病，其引发的疾病负担极为沉重；在全球伤残调整生命年（Disability-Adjusted Life Years, DALY）的测算维度中，其疾病负担可与糖尿病、肺癌比肩。尽管在药物可及性与公共卫生基础设施建设领域取得了一定进展，但绝大多数蠕虫病仍是难以攻克的棘手问题。本研究以罗阿丝虫（L. loa）及其他线虫为研究对象，将为构建蠕虫寄生虫遗传多样性的完整图谱提供必要资源，进而长期改善人体蠕虫感染症（helminthiasis）的分子分型水平，并实现对耐药性传播的监测与管控。