HISTOGENESIS OF THE MALE REPRODUCTIVE SYSTEM

Histogenesis of the male reproductive system is a tightly coordinated developmental sequence in which genetic sex determination is translated into organ-level differentiation of the testes, the ductal system, accessory glands, and external genitalia. The process begins with formation of the urogenital ridge and migration of primordial germ cells, proceeds through testis determination driven by a somatic cell program, and culminates in androgen- and peptide-mediated remodeling of embryonic ducts and the urogenital sinus.雄性生殖系统的组织发生是一套高度协调的发育时序，遗传性别决定可转化为睾丸、导管系统、附属腺及外生殖器的器官水平分化。该过程起始于尿生殖嵴的形成与原始生殖细胞的迁移，历经体细胞程序驱动的睾丸决定阶段，最终以雄激素与肽类物质介导的胚胎导管及尿生殖窦重塑完成发育全程。