The relationship between topical anti-glaucoma medications and the development of lacrimal drainage system obstruction

ABSTRACT Purpose: To evaluate whether any topical anti-glaucoma medications increase the risk of lacrimal drainage system obstruction or whether the presence of preservatives alone is sufficient to generate obstruction. Methods: This nested case-control study compared a group of patients with lacrimal duct obstruction who received topical anti-glaucoma medications to a control group of patients without obstruction. Results: The medical records of 255 patients with glaucoma who consulted the Oculoplastic Section with complaints of watery eyes were reviewed. Among these patients, 59 exhibited lacrimal drainage obstruction. Ninety-four percent of patients with lacrimal drainage obstruction used beta-blockers, and 41% used prostaglandin analogs. A logistic regression model was used to adjust for age, sex, and the use of other medications. No significant differences were observed regarding the topical anti-glaucoma medications used between groups. Conclusion: No single topical anti-glaucoma medication demonstrated a stronger association with the development of lacrimal duct obstruction.

摘要
目的：旨在评估局部抗青光眼药物是否会增加泪液引流系统阻塞的风险，抑或仅防腐剂的存在即可引发阻塞。
方法：本研究为巢式病例对照研究，将罹患泪道阻塞且使用局部抗青光眼药物的患者组，与无阻塞的对照组患者进行对比。
结果：本研究回顾了255名因流泪症状就诊于眼整形科的青光眼患者的病历资料。其中59例存在泪液引流阻塞。存在泪液引流阻塞的患者中，94%使用了β受体阻滞剂，41%使用了前列腺素类似物。本研究采用logistic回归模型对年龄、性别及其他药物使用情况进行校正。两组患者所使用的局部抗青光眼药物未呈现显著差异。
结论：未发现任何一种局部抗青光眼药物与泪道阻塞的发生存在更强的相关性。