Additional file 2 of The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies

Additional file 2: Figure S1. Contour-enhanced funnel plots associating dietary patterns or diet quality indices with RCC incidence: A) healthy dietary pattern, B) unhealthy/Western pattern, C) drinking pattern, D) dietary inflammatory index, E) glycemic index, and F) glycemic load. Figure S2. Contour-enhanced funnel plots associating foods with RCC incidence: A) fish, B) vegetables, C) fruits, D) red meat, E) processed meat, and F) cruciferous vegetables. Figure S3. Contour-enhanced funnel plots associating foods with RCC incidence: A) poultry, B) all meat, C) fruit and non-starchy vegetables, D) non-starchy vegetables, E) tomatoes, and F) citrus fruit. Figure S4. Contour-enhanced funnel plots associating beverages with RCC incidence: A) sweet beverages (including artificially sweetened beverages and sugar-sweetened beverages), B) tea, C) coffee, and D) sweetened carbonated beverage. Figure S5. Contour-enhanced funnel plots associating alcoholic beverages with RCC incidence: A) beer, B) wine, C) spirits, D) alcohol (light), E) alcohol (moderate), F) alcohol (heavy), and G) alcohol (any). Figure S6. Contour-enhanced funnel plots associating macronutrients with RCC incidence: A) fruit fiber, B) vegetable fiber, C) cereal fiber, D) dietary fiber, E) Total fat, and F) saturated fat. Figure S7. Contour-enhanced funnel plots associating macronutrients with RCC incidence: A) monounsaturated fat, B) polyunsaturated fat, C) total protein, D) animal protein, and E) plant protein. Figure S8. Contour-enhanced funnel plots associating micronutrients with RCC incidence: A) riboflavin, B) vitamin B6, C) folate, D) vitamin B12, E) methionine, and F) choline. Figure S9. Contour-enhanced funnel plots associating micronutrients with RCC incidence: A) betaine, B) vitamin C, C) vitamin D, D) dietary nitrate, E) dietary nitrite, and F) vitamin E. Figure S10. Contour-enhanced funnel plots associating micronutrients with RCC incidence: A) alpha-carotene, B) beta-cryptoxanthin, C) lutein and zeaxanthin, D) dietary lycopene, E) total calcium (food and supplements), F) dietary calcium, and G) Calcium (supplements). Figure S11. After using the trim-and-fill method, contour-enhanced funnel plots for the association between A) vegetables, B) red meat, C) vegetable fiber, D) fruit and non-starchy vegetables, and E) lutein and zeaxanthin and the incidence of renal cell carcinoma were generated.

附加文件2：图S1：关联饮食模式或饮食质量指数与肾细胞癌（renal cell carcinoma, RCC）发病率的等高线增强漏斗图：A）健康饮食模式，B）不健康/西方饮食模式，C）饮酒模式，D）饮食炎症指数，E）血糖指数，F）血糖负荷。图S2：关联食物与肾细胞癌发病率的等高线增强漏斗图：A）鱼类，B）蔬菜，C）水果，D）红肉，E）加工肉类，F）十字花科蔬菜。图S3：关联食物与肾细胞癌发病率的等高线增强漏斗图：A）禽肉，B）全肉类，C）水果与非淀粉类蔬菜，D）非淀粉类蔬菜，E）番茄，F）柑橘类水果。图S4：关联饮料与肾细胞癌发病率的等高线增强漏斗图：A）甜饮料（含人工甜味剂饮料与含糖饮料），B）茶，C）咖啡，D）甜碳酸饮料。图S5：关联酒精饮料与肾细胞癌发病率的等高线增强漏斗图：A）啤酒，B）葡萄酒，C）烈酒，D）少量饮酒，E）中等量饮酒，F）大量饮酒，G）任意量饮酒。图S6：关联宏量营养素与肾细胞癌发病率的等高线增强漏斗图：A）水果纤维，B）蔬菜纤维，C）谷物纤维，D）膳食纤维，E）总脂肪，F）饱和脂肪。图S7：关联宏量营养素与肾细胞癌发病率的等高线增强漏斗图：A）单不饱和脂肪，B）多不饱和脂肪，C）总蛋白质，D）动物蛋白，E）植物蛋白。图S8：关联微量营养素与肾细胞癌发病率的等高线增强漏斗图：A）核黄素，B）维生素B6，C）叶酸，D）维生素B12，E）蛋氨酸，F）胆碱。图S9：关联微量营养素与肾细胞癌发病率的等高线增强漏斗图：A）甜菜碱，B）维生素C，C）维生素D，D）膳食硝酸盐，E）膳食亚硝酸盐，F）维生素E。图S10：关联微量营养素与肾细胞癌发病率的等高线增强漏斗图：A）α-胡萝卜素，B）β-隐黄质，C）叶黄素与玉米黄质，D）膳食番茄红素，E）总钙（食物与补充剂），F）膳食钙，G）补充剂钙。图S11：采用剪补法（trim-and-fill method）后，生成的关联A）蔬菜、B）红肉、C）蔬菜纤维、D）水果与非淀粉类蔬菜、E）叶黄素与玉米黄质与肾细胞癌发病率的等高线增强漏斗图。