RNAseq data comparing KRAS*-independent HDAC5 eccaper PDAC cells and KRAS*-dependent iKPC PDAC cells. RNAseq data comparing KRAS*-independent HDAC5 eccaper PDAC cells and KRAS*-dependent iKPC PDAC cells

HDAC5 drives PDAC cells to bypass KRAS* dependency. To dissect the molecular mechanisms that regulated by overexpressed HDAC5 in the bypass of KRAS* dependency, we conducted RNA-seq analysis of HDAC5 escaper PDAC cells and KRAS*-expressing iKPC PDAC cells. Overall design: Four KRAS* expressing iKPC PDAC cell lines and five HDAC5 escaper PDAC cell lines were used.

组蛋白去乙酰化酶5（HDAC5）可促使胰腺导管腺癌细胞（PDAC）绕过KRAS*依赖特性。为解析过表达HDAC5调控细胞绕过KRAS*依赖特性的分子机制，我们对HDAC5逃逸型PDAC细胞与表达KRAS*的iKPC PDAC细胞开展了RNA测序（RNA-seq）分析。实验整体设计：本研究共使用4株表达KRAS*的iKPC PDAC细胞系及5株HDAC5逃逸型PDAC细胞系。