Supporting data for “IN-DEPTH STUDY OF ABERRANT CHROMATIN REGULATORS IN HEPATOCELLULAR CARCINOMA DEVELOPMENT”

Raw data for the research projects regarding the thesis “IN-DEPTH STUDY OF ABERRANT CHROMATIN REGULATORS IN HEPATOCELLULAR CARCINOMA DEVELOPMENT” for Ph.D. degree examination.

Three projects are included:

The first project investigated the oncogenic role of VPS72 in HCC which we previously reported it genetic amplification in liver cancer patients. In this thesis, we revealed an important master regulatory gene whos expression is repressed by excessive VPS72 and subsequently failed to maintain the metabolic balance in HCC cells.

The second project explored the previously reported protein-protein interaction of SIRT7 with NRF2 and how SIRT7 regulates the chronic activation of NRF2 signaling in HCC cells.

The third project is a side project conducted during the research to facilitate the design of molecular cloning. The McDesigner is a swift webserver able to provide various reliable molecular cloning strategies case by case.

本数据集包含针对博士学位论文《肝细胞癌发展中异常染色质调节因子的深入研究》相关研究项目的原始数据。数据集共涵盖三项研究项目：

第一项研究探讨了VPS72在肝细胞癌（HCC）中的致癌作用，我们此前曾报道其在肝癌患者中的基因扩增现象。在本论文中，我们揭示了表达受VPS72过度抑制的关键调控基因，其表达受抑导致HCC细胞代谢平衡失衡。

第二项研究对已报道的SIRT7与NRF2之间的蛋白质-蛋白质相互作用进行了探究，并分析了SIRT7如何调节HCC细胞中NRF2信号通路的慢性激活。

第三项研究为辅助分子克隆设计的研究分支项目。McDesigner是一款快速网络服务器，能够根据具体案例提供可靠的分子克隆策略。