Additional file 1 of Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study

Additional file 1: Table S1. Information of instrumental variables for all exposure-outcome pairs in forward Mendelian randomization analyses. Table S2. Information of instrumental variables for all exposure-outcome pairs in reverse Mendelian randomization analyses. Table S3. Forward Mendelian randomization analysis results. Table S4. Forward Mendelian randomization analysis results after removing the overlapping single nucleotide polymorphisms between exposure phenotypes. Table S5. Reverse Mendelian randomization analysis results. Table S6. Reverse Mendelian randomization analysis results after removing the overlapping single nucleotide polymorphisms between exposure phenotypes. Table S7. Descriptions of study cohorts participating in the genome-wide association studies meta-analysis to identify genetic variants associated with human cortical structure. Table S8. Descriptions of study cohorts participating in the genome-wide association studies meta-analysis to identify genetic variants associated with human subcortical brain structures. Table S9. Descriptions of study cohorts participating in the genome-wide association studies meta-analysis to identify genetic variants associated with longitudinal changes in brain structure across the lifespan.

附加文件1：表S1。正向孟德尔随机化（Mendelian randomization）分析中所有暴露-结局对的工具变量信息。表S2。反向孟德尔随机化（Mendelian randomization）分析中所有暴露-结局对的工具变量信息。表S3。正向孟德尔随机化分析结果。表S4。剔除暴露表型间重叠单核苷酸多态性（single nucleotide polymorphisms，SNP）后的正向孟德尔随机化分析结果。表S5。反向孟德尔随机化分析结果。表S6。剔除暴露表型间重叠单核苷酸多态性后的反向孟德尔随机化分析结果。表S7。参与全基因组关联研究（genome-wide association studies，GWAS）元分析以鉴定与人类皮层结构相关遗传变异的研究队列描述。表S8。参与全基因组关联研究元分析以鉴定与人类皮层下脑结构相关遗传变异的研究队列描述。表S9。参与全基因组关联研究元分析以鉴定与全生命周期脑结构纵向变化相关遗传变异的研究队列描述。