Campylobacter jejuni strain:RM1285 Genome sequencing and assembly

Campylobacter spp. are responsible for the largest number of foodborne gastrointestinal bacterial infections in the developed world. The majority of these human cases of campylobacteriosis are cause by the species Campylobacter jejuni. Poultry products are a primary environmental pathway by which C. jejuni are introduced into the food supply. However, C. jejuni are nutritionally fastidious micro-anaerobes making them unlikely candidates to persist in the environment in sufficient numbers to cause such a large amount of human disease. In this study we fully sequenced and annotated C. jejuni strain RM1285 an environmental isolate from chicken that has revealed unique characteristics. Morphologically, RM1285 is rod shaped compared to the spiral form most common to other C. jejuni strains. Additionally, strain RM1285 has demonstrated increased resistance to inactivation by high hydrostatic pressure compared to other C. jejuni strains.

弯曲杆菌属（Campylobacter spp.）是发达国家食源性胃肠道细菌感染的首要致病原。其中绝大多数人类弯曲菌病（campylobacteriosis）病例由空肠弯曲杆菌（Campylobacter jejuni）引发。禽肉制品是空肠弯曲杆菌进入食品供应链的主要环境传播途径。然而，空肠弯曲杆菌属于营养苛求型微需氧菌，难以在环境中维持足够数量以引发大规模人类感染。本研究对从鸡源环境中分离得到的空肠弯曲杆菌菌株RM1285进行了全基因组测序与注释，该菌株展现出独特特性：在形态上，相较于多数其他空肠弯曲杆菌菌株的螺旋形态，RM1285呈杆状；此外，相较于其他空肠弯曲杆菌菌株，RM1285对高静水压（high hydrostatic pressure）灭活的抗性显著增强。