DMAP Promoted Tandem Addition Reactions Forming Substituted Tetrahydroxanthones

Substituted
tetrahydroxanthones are constructed using a DMAP-promoted
tandem nucleophilic addition process. The reaction yields range from
39% to 73%. Disubstituted tetrahydroxanthones are generated as a ∼2.3:1
mixture of diastereomers favoring the formation of the trans-isomer.

取代四氢吨酮（tetrahydroxanthones）通过4-二甲氨基吡啶（DMAP）介导的串联亲核加成反应构建得到。该反应的产率范围为39%至73%。双取代四氢吨酮以约2.3:1的非对映异构体混合物形式生成，反式异构体（trans-isomer）为优势产物。