Use of cyanoacrylate-based surgical adhesives associated to the macroporous tape in skin synthesis in rats

Abstract Purpose: To compare the use of new cyanoacrylate surgical adhesive associated with macroporous tapes in cutaneous synthesis. Methods: Male Wistar rats with a longitudinal incision of 4cm were used on the back, divided into four groups: GI used octyl-cyanoacrylate (Dermabond®), GII used N-2-butylcyanoacrylate, GIII used octyl-cyanoacrylate and macroporous tape and GIV used N-2-butyl cyanoacrylate and macroporous tape. On the fourteenth day, the rats were submitted to euthanasia, were divided in two parts, and a layer of skin subcutaneous tissue through an area of operative healing was removed. One part was submitted to the study of rupture strength with the use of tensiometer, and in the other part histological examination was performed. Results: No force test was similar between groups I and II, being different from groups III and IV (P <0.001), which were identical to each other (P> 0.05). The units were compared among the studied groups, and they were different with the use of macroporous tapes (P> 0.05). Conclusions: The purpose of macroporous tapes is associated with CA adhesives in cutaneous tissues that provide more resistant scars. The use of a combination of macroporous tapes leads to complete re-epithelialization, without provoking foreign body reaction, has hemostatic properties and does not cause an absorptive reaction.

【摘要】目的：比较新型氰基丙烯酸酯（cyanoacrylate）手术粘合剂联合大孔胶带（macroporous tapes）在皮肤缝合中的应用效果。
方法：选取雄性Wistar大鼠，于背部制作4cm纵向切口，将其分为四组：GI组使用辛基氰基丙烯酸酯（Dermabond®），GII组使用N-2-丁基氰基丙烯酸酯，GIII组使用辛基氰基丙烯酸酯联合大孔胶带，GIV组使用N-2-丁基氰基丙烯酸酯联合大孔胶带。术后第14天对大鼠实施安乐死，取手术愈合区域的皮肤及皮下组织标本，将标本分为两份：一份采用张力仪（tensiometer）检测断裂强度，另一份进行组织病理学检查。
结果：I组与II组的断裂强度无统计学差异，且二者与III、IV组存在显著差异（P<0.001）；III组与IV组的断裂强度无统计学差异（P>0.05）。对各组的相关指标进行比较后发现，使用大孔胶带的组间差异无统计学意义（P>0.05）。
结论：大孔胶带联合氰基丙烯酸酯粘合剂可提升皮肤组织术后瘢痕的抗张强度。联合使用大孔胶带可促进上皮完全再生，不会引发异物反应，具备止血特性且不会出现吸收性反应。