HGDS HIV Viral Load Dataset in Hemophilia Growth and Development Study

HIV viral load test results
Study Description
A multicenter study of hemophilia and its complications, HGDS was established in 1988. Data were prospectively collected in 14 US hemophilia treatment centers through 1996/97. The HGDS investigated the effects of hemophilia and HIV on physical growth and maturation; immunological, neurological, and neuropsychological functioning; and the pathophysiology of HIV and hepatitis C. Research using the clinical data and stored samples continues and includes the genetic research that paved the way for development of the protease inhibitors currently used to treat HIV; studies that provided clues to viral characteristics of HIV and hepatitis B and C; research to identify genetic factors associated with the development of inhibitory antibodies to factor VIII; the relationship of inhibitors to cognitive development and academic achievement; studies of viral factors and how they relate to progression of HIV and hepatitis C; and research on the parenteral transmission of human viruses. Biospecimens are available. Children and adolescents ages 6 to 19 with hemophilia (n=333), with and without HIV infection, and a subset of their unaffected male siblings (n=47)

HIV病毒载量检测结果
研究概述
本研究为一项针对血友病及其并发症的多中心研究——血友病生长发育研究（Hemophilia Growth and Development Study, HGDS），于1988年启动。研究数据于1996至1997年间，通过美国14家血友病治疗中心前瞻性收集。HGDS旨在探究血友病与HIV对个体体格生长及发育成熟的影响、免疫功能、神经功能与神经心理学表现，以及HIV与丙型肝炎的病理生理学机制。基于本研究临床数据与留存生物样本的后续研究仍在持续开展，涵盖：为当前临床用于治疗HIV的蛋白酶抑制剂研发奠定基础的遗传学研究；揭示HIV、乙型肝炎与丙型肝炎病毒特征的相关研究；明确与VIII因子抑制性抗体产生相关的遗传因素的研究；抑制性抗体与认知发育及学业成就关联的研究；病毒因素及其与HIV、丙型肝炎病情进展相关性的研究；以及人类病毒经肠外途径传播的相关研究。本研究可提供生物样本。研究对象包括333名6至19岁的血友病患儿及青少年（其中部分合并HIV感染，部分未感染），以及其47名未受影响的男性同胞亚组。