RNA-seq data of the kidneys of diabetic nephropathy rats treated with TSK

TSK (TangShenKang) is a compound traditional Chinese medicine. To explore the core corresponding program of this medicine acting on diabetic kidneys, RNA-seq was conducted on rats kidney tissues under different treatments in this study. Specifically, this experiment was divided into three groups (6 rats in each group) : Normal control group (Ctrl) , DN model group, treatment group. Overall design: 6 rats in each group: control group (Ctrl) (ordinary feed + solvent gavage), the DN model group (high-fat diet +STZ injection to induce DN), and the treatment group (DN + TSK) (TSK 500 mg/kg/d oral administration, treated for 4 weeks).

TSK（TangShenKang）为复方中药。为探究该药物作用于糖尿病肾病（DN）肾脏的核心作用机制，本研究针对不同处理条件下的大鼠肾脏组织开展了RNA测序（RNA-seq）实验。具体而言，本实验设置三组（每组6只大鼠）：正常对照组（Ctrl）、糖尿病肾病模型组与给药组。实验整体设计如下：每组均包含6只大鼠，其中正常对照组（Ctrl）给予普通饲料并辅以溶剂灌胃；糖尿病肾病模型组采用高脂饮食联合链脲佐菌素（STZ）注射以诱导糖尿病肾病；给药组（DN+TSK）以500mg/kg/d的剂量口服给予TSK，连续给药4周。