Synthesis and Reactivity of 5‑Heterotruxenes Containing Sulfur or Nitrogen as the Heteroatom

This paper presents an alternative
path for the synthesis of 5-thiatruxene
and the synthetic approach for 5-azatruxene not known so far. A new
method for 5-thiatruxene improves the overall reaction yield from
17.5 to 22.6%, diminishes the synthesis time and costs by reducing
synthetic steps from 5 to 2, and simplifies the isolation of intermediate
and final products. The overall reaction yield for 5-azatruxene is
32.4%. The typical reactivity of both aromatic systems is also demonstrated.
Recent research results suggest the use of 5-thiatruxene as the acceptor
subunit of soluble blue emitters.

本研究提出了5-硫杂曲烯（5-thiatruxene）的替代性合成路径，同时首次开发了迄今尚未见报道的5-氮杂曲烯（5-azatruxene）合成方法。针对5-硫杂曲烯的新型合成方案将总反应产率从17.5%提升至22.6%，通过将合成步骤从5步精简至2步，缩短了合成周期、降低了合成成本，并简化了中间体与最终产物的分离提纯流程。5-氮杂曲烯的总反应产率可达32.4%。两类芳香体系的典型反应活性亦得到了验证。近期研究成果表明，5-硫杂曲烯可作为可溶性蓝色发光体的受体亚基加以应用。