PARP15 catalytic domain in complex with OUL218 Descriptor: 4-(1,3-thiazol-5-ylmethoxy)benzamide, DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15 Authors: Maksimainen, M.M, Murthy, S, Le
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytoto
Analysis of the role of PARP1 in gene transcription in cell lines with variable PARP1 activity. Overall design: Total RNA was collected from MCF7, KPL-1, ZR7530, T47D, SKBR3, and Hs578T cells that had
(A) Representative Western blot of whole cell extracts from cells treated with the inhibitor PJ34 (5μM) at the indicated times relative to untreated cells (NT, value ~1), run on a 15% SDS-PAGE, and pr