Cytotoxic p‑Terphenyls from a Marine-Derived Nocardiopsis Species

Three new p-terphenyl derivatives, nocarterphenyls A–C (1–3), along with three known analogues (4–6) were isolated from the marine-derived actinobacterial strain Nocardiopsis sp. OUCMDZ-4936. Their structures were elucidated on the basis of spectroscopic analysis and a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possess a benzothiazole and benzothiazine moiety, respectively, which are rare in the skeleton of p-terphenyls. Nocarterphenyl A (1) showed potent cytotoxic activity against the HL60 and HCC1954 cancer cell lines with the IC50 values of 0.38 and 0.10 μM among 26 human cancer cell lines.

从海洋来源放线菌菌株诺卡氏菌属（Nocardiopsis）sp. OUCMDZ-4936中，分离得到3个新的对三联苯（p-terphenyl）衍生物诺卡三联苯A–C（1–3），以及3个已知类似物（4–6）。通过光谱分析与单晶X射线衍射实验，阐明了它们的化学结构。化合物1与2分别含有苯并噻唑（benzothiazole）与苯并噻嗪（benzothiazine）片段，这类结构在对三联苯骨架中较为罕见。在26株人源癌细胞系的活性筛选中，诺卡三联苯A（1）对HL60与HCC1954癌细胞系表现出强效细胞毒活性，其半数抑制浓度（IC50）分别为0.38与0.10 μM。