Plasmodium vivax AmpliSeq Assay. Plasmodium vivax

The Centers for Disease Control and Prevention (CDC) developed a highly-multiplex genotyping based AmpliSeq assay to monitor the surveillance of imported Plasmodium vivax (Pv) cases in the United States from Pv endemic regions. The goal of this project is to 1) report the drug resistance mutations for the P.vivax molecular resistance markers, 2) Predict the geographic origin of the P.vivax infected samples and 3) Genetic clustering to identify the closely related P.vivax strains.

美国疾病控制与预防中心（Centers for Disease Control and Prevention, CDC）开发了一种基于多重高通量基因分型的AmpliSeq检测技术，用于监测美国境内来自间日疟原虫（Plasmodium vivax, Pv）流行地区的输入性间日疟病例。本项目的研究目标如下：1）报告间日疟原虫分子耐药标记物对应的耐药突变信息；2）预测间日疟原虫感染样本的地理来源；3）通过遗传聚类分析鉴定亲缘关系相近的间日疟原虫毒株。