Human LRH-1 bound to the agonist 6N and a fragment of the Tif2 coregulator

Human LRH-1 bound to the agonist 6N and a fragment of the Tif2 coregulator Descriptor: N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]sulfuric diamide, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 Authors: Mays, S.G, Ortlund, E.A. Deposit date: 2019-04-29 Release date: 2019-08-28 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J.Med.Chem., 62, 2019

本数据集收录结合激动剂6N（化学名：N-[(1S,3aR,6aR)-5-己基-4-苯基-3a-(1-苯乙烯基)-1,2,3,3a,6,6a-六氢戊搭烯-1-基]硫酸二酰胺）的人源肝受体同源物1（Liver Receptor Homolog-1, LRH-1，核受体亚家族5A组2成员，Nuclear receptor subfamily 5 group A member 2）与Tif2共调节因子（核受体共激活因子2，Nuclear receptor coactivator 2）片段的复合物结构相关信息。作者：Mays S.G.、Ortlund E.A.。存储日期：2019-04-29；发布日期：2019-08-28；最后修改日期：2023-10-11。实验方法：X射线衍射（分辨率2.23 Å）。引用文献：《通过结构导向设计开发首个低纳摩尔级肝受体同源物1激动剂》，《药物化学杂志》（J.Med.Chem.），第62卷，2019年。