Mice MR Images (lungs and pulmonary metastases)

55 mice were imaged after injection on a 7T Bruker BioSpec system equipped with a gradient coil of 660 mT/m maximum strength and 110 μs rise time. 27 mice with Crispr/Cas9 il34 KO gene and 28 controls. Animals were imaged every week: from day 6 to day 32 post-implantation for control mice and from day 8 till their condition deteriorated (up to day 141 at most) for il34 mice. Two additional healthy mice were scanned 3 times, two times without repositioning and one time after waking them up in order to evaluate the reproducibility of the lungs’ segmentations. The balanced Steady State Free Precession (bSSFP) sequence was chosen, as it has previously been shown that high tumor contrast can be obtained in the brain and in the liver (https://doi.org/10.1002/jmri.21449 ; https://doi.org/10.1002/jmri.22593 ; https://doi.org/10.1002/jmri.24688). Combined with the Self-Gating (SG) method, it enables to delete echoes affected by motion and consequently obtain abdominal images without motion artifact (https://doi.org/10.1002/jmri.24688). Corresponding masks were manually drawn around the lungs on every slice of 185 3D images; masks were manually drawn around the pulmonary metastases on every slice of 62 3D images containing metastases. Both tasks were performed by two different investigators.本数据集涵盖55只小鼠的磁共振成像数据：所有小鼠经注射后，于7T Bruker BioSpec成像系统完成扫描，该系统配备最大强度为660 mT/m的梯度线圈，上升时长为110 μs。其中27只为经Crispr/Cas9技术构建的il34基因敲除（KO）小鼠，剩余28只为对照小鼠。所有小鼠均按周接受成像：对照小鼠于植入术后第6天至第32天进行扫描，il34 KO小鼠则从植入术后第8天开始每周扫描，直至其健康状态恶化（最长扫描至第141天）。另有2只健康小鼠接受3次扫描：其中2次未进行体位重新定位，1次在唤醒后完成扫描，用于评估肺部分割的可重复性。本研究选用平衡式稳态自由进动（balanced Steady State Free Precession, bSSFP）序列，既往研究已证实该序列可在脑部与肝脏组织中获得优异的肿瘤对比度（参考文献：https://doi.org/10.1002/jmri.21449；https://doi.org/10.1002/jmri.22593；https://doi.org/10.1002/jmri.24688）。结合自门控（Self-Gating, SG）技术，该序列可剔除受运动干扰的回波信号，进而获取无运动伪影的腹部磁共振图像（参考文献：https://doi.org/10.1002/jmri.24688）。针对185幅3D图像的每一层切片，研究者均手动在肺部区域周围绘制对应的分割掩码；针对62幅包含肺转移瘤的3D图像的每一层切片，研究者均手动在肺转移瘤区域周围绘制分割掩码。两项标注任务均由两名独立的研究者分别完成。