Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts

A catalytic enantioselective and regiodivergent arylation of alkenes is described. Chiral copper­(II)­bisoxazoline complexes catalyze the addition of diaryliodonium salts to allylic amides in excellent ee. Moreover, the arylation can be controlled by the electronic nature of the diaryliodonium salt enabling the preparation of nonracemic diaryloxazines or β,β′-diaryl enamides.

本研究报道了一种烯烃的催化对映选择性区域发散型芳基化反应。手性铜(II)-双恶唑啉配合物可催化二芳基碘鎓盐与烯丙基酰胺发生加成反应，产物可获得优异的对映体过量值（enantiomeric excess, ee）。此外，通过调控二芳基碘鎓盐的电子性质，可精准控制该芳基化反应的路径，从而制备得到非消旋的二芳基恶嗪或β,β′-二芳基烯酰胺。