Analysis of Enterobacteriaceae harbouring the blaKPC carbapenemase gene. Genome sequencing and assembly

These isolates represent a dataset assembled by the TRACE (Tracking Carbapenemase-producing Enterobacteriaceae) Investigators' Group (Manchester hospitals; University of Oxford; Public Health England), and used to describe the genomic epidemiology of KPC-positive isolates (n=604) in the UK, 2009-2014. This study focused on a KPC-associated outbreak thought to have started in 2009, which rapidly became endemic in Manchester hospitals. Regional isolates from the North West region (i.e. around Manchester), and isolates from a national collection maintained by the Antimicrobial Resistance and Healthcare-associated Infections (AMRHAI) reference laboratory, UK, were included to understand the wider context and genomic picture during the study period.

本数据集由TRACE（Tracking Carbapenemase-producing Enterobacteriaceae，碳青霉烯酶产生肠杆菌科追踪）研究组（由曼彻斯特各医院、牛津大学及英国公共卫生署组成）构建，用于描述2009年至2014年英国境内604株KPC阳性分离株的基因组流行病学特征。本研究聚焦于一场推测始于2009年的KPC相关暴发疫情，该疫情随后在曼彻斯特各医院迅速演变为地方性流行。为阐明研究周期内的宏观流行病学背景与全基因组特征，研究纳入了英格兰西北部（即曼彻斯特周边区域）的区域性分离株，以及由英国抗菌药物耐药与医疗相关感染（Antimicrobial Resistance and Healthcare-associated Infections, AMRHAI）参考实验室保藏的全国性分离株。