Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Homo sapiens

Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably the expansion of Tregs and the decrease of Th1 and Th17 cells. A significant correlation between higher disease activity and lower serum 25-hydroxyvitamin D levels was also shown. This preliminary study suggests the beneficial role of vitamin D in SLE patients and needs to be confirmed in randomized controlled trials. Overall design: In this prospective study, we evaluated the safety and the immunological effects of vitamin D supplementation in 20 SLE patients with hypovitaminosis D using transcriptomic study at M0 and M2.

系统性红斑狼疮（Systemic lupus erythematosus, SLE）是一种T、B细胞依赖型自身免疫性疾病，以自身抗体产生、全局性调节性T细胞（regulatory T cells, Tregs）耗竭及Th17细胞增多为主要特征。近期研究显示，维生素D具有多层面的免疫调节作用，具体表现为扩增调节性T细胞、降低Th1与Th17细胞的数量。另有研究证实，疾病活动度更高的患者其血清25-羟维生素D水平显著更低，二者存在显著相关性。本初步研究提示维生素D对系统性红斑狼疮患者具有潜在获益价值，但该结论仍需通过随机对照试验予以证实。
研究整体设计：本前瞻性研究共纳入20例伴维生素D缺乏的系统性红斑狼疮患者，于基线（M0）及随访第2个月（M2）开展转录组学研究，以此评估维生素D补充治疗的安全性与免疫学效应。