Association of MASP1 variants and haplotypes with leprosy.

The intron 1 and exon 12 haplotypes were unambiguously build with sequence-specific amplification. The phase between them (symbolized by “_”) was inferred using the expectation maximization algorithm. Official SNP nomenclature is given within parenthesis for the longest cDNA, corresponding to the mRNA transcript encoding MASP-1: ENST00000337774.9. Addit: Additive association model, which tests the hypothesis that homozygosity and heterozygosity for the minor allele are associated with leprosy (either with protection or with susceptibility), but homozygosity is stronger associated, than heterozygosity. Dom: Dominant association model, which tests the hypothesis that the carrier status of the minor allele (regardless if homozygous or heterozygous) is associated with leprosy (either with protection or with susceptibility). All associations were corrected for age, which was the only demographic factor that remained associated in the reduced model of logistic regression. *: GT_GTG + GT_CTG association. q*: Benjamini-Hochberg corrected p values; ns: not significant; OR: odds ratio; CI: confidence interval.