Crystal Structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 A resolution.

Crystal Structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 A resolution. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, C-terminal peptidase, ... Authors: Del Amo-Maestro, L, Eckhard, U, Rodriguez-Banqueri, A, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X. Deposit date: 2022-05-14 Release date: 2022-08-10 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy. Nat Commun, 13, 2022

分辨率为1.80 Å的谷氨酰类脯氨酰内肽酶neprosin天然酶原形式的晶体结构。配体描述：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、乙酸根离子、C端肽酶等。作者：Del Amo-Maestro, L、Eckhard, U、Rodriguez-Banqueri, A、Mendes, S.R、Guevara, T、Gomis-Ruth, F.X。存档日期：2022-05-14；发布日期：2022-08-10；末次修改日期：2024-10-16。实验方法：X射线衍射（1.8 Å）。引用文献：《用于乳糜泻治疗的谷氨酰类脯氨酰内肽酶的分子与体内研究》，《自然-通讯》，第13卷，2022年。