Small RNA sequencing of Bovine leukemia virus and Bovine foamy virus naturally infected cattle

We identified the expression of BFV- and BLV-derived miRNAs in naturally BLV-infected cattle. Also, bovine miRNAs were differentially expressed between BLV/BFV-infected cattle and BLV-uninfected animals. Functional analysis of the protein-protein interaction network of genes potentially targeted by both viral- and host-derived miRNAs revealed key metabolic pathways involved in tumorigenesis and immune response regulation in cattle.

本研究在自然感染牛白血病病毒（BLV, Bovine Leukemia Virus）的牛只中，鉴定得到牛泡沫病毒（BFV, Bovine Foamy Virus）源性与BLV源性微小RNA（miRNA）的表达水平。此外，感染BLV/BFV的牛只与未感染BLV的牛只之间，牛源微小RNA呈现显著差异表达。通过对病毒源与宿主源miRNA潜在靶向基因的蛋白质相互作用网络开展功能分析，本研究揭示了牛体内参与肿瘤发生及免疫应答调控的关键代谢通路。