Toxicogenomic responses in rainbow trout hepatocytes exposed to model chemicals and a synthetic mixture. Oncorhynchus mykiss

Comparison of gene expression of exposed versus non-exposed Oncorhynchus mykiss hepatocytes to four model chemicals and a synthetic mixture. Hepatocytes were exposed for 24 hours to a single chemical and a synthetic mixture of 10 nM 17 alpha-ethinylestradiol (EE2), 0.75 nM 2,3,7,8-tetrachloro-di-benzodioxin (TCDD), 100 μM paraquat and 0.75 μM 4-nitroquinoline-1-oxide (NQO). Keywords: Exposed vs. control Overall design: Four biological replicates for both exposed and non-exposed Oncorhynchus mykiss hepatocytes with corresponding dye flips.

本数据集针对暴露于四种模式化学物及人工合成混合物与未暴露的虹鳟（Oncorhynchus mykiss）肝细胞开展基因表达水平对比分析。
肝细胞分别暴露于四种单一模式化学物，以及由10 nM 17α-乙炔基雌二醇（17 alpha-ethinylestradiol, EE2）、0.75 nM 2,3,7,8-四氯二苯并二噁英（2,3,7,8-tetrachloro-di-benzodioxin, TCDD）、100 μM 百草枯（paraquat）与0.75 μM 4-硝基喹啉-1-氧化物（4-nitroquinoline-1-oxide, NQO）组成的人工合成混合物，暴露时长均为24小时。
关键词：暴露组vs.对照组
实验设计：暴露组与未暴露组的虹鳟肝细胞均设置4个生物学重复，并配套开展染料翻转实验。