H3122, in vitro resistance to ALK inhibitors. H3122, in vitro resistance to ALK inhibitors

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures Overall design: 6 samples comparing drug naïve cells to cells resistant to various ALK inhibitors, no replicates

靶向治疗（targeted therapies）耐药属于多因素驱动、针对抑制剂特异性选择压力的渐进性适应过程。实验整体设计：共设置6份样本，对比未接触药物的细胞与对多种ALK抑制剂（ALK inhibitors）产生耐药的细胞，未设置生物学重复。