Iron-Catalyzed Regioselective Direct Arylation at the C‑3 Position of <i>N</i>‑Alkyl-2-pyridone

A number of pharmaceutical compounds possess an arylated 2-pyridone moiety. The existing reports using expensive starting materials and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method for their synthesis. In this report, we demonstrate an easy-to-handle reaction condition with an iron catalyst for the exclusive generation of C-3-arylated pyridone via C–H functionalization.诸多药物化合物均含有芳基化2-吡啶酮（2-pyridone）结构片段。现有相关研究多采用昂贵起始原料或超化学计量金属盐来合成这类化合物，这促使我们探索开发一种简便易用的合成方法。本文报道了一种以铁催化剂构建的易于操作的反应条件，可通过C-H键官能化（C–H functionalization）专一性制备C-3位芳基化吡啶酮。