Seasonal Patterns of Vogt–Koyanagi–Harada Disease

To identify the relationship between the incidence of Vogt–Koyanagi–Harada (VKH) disease and seasonality. A retrospective cohort study was performed, including patients with a confirmed diagnosis of VKH whose month of disease onset was available. Information on patients was entered retrospectively into a database and analyzed according to the month and season. Twenty-four patients who met the inclusion criteria were included in the analysis. There was a statistically significant deviation from expected values in the incidences of VKH per season (P = .043). The most common season for the onset of VKH was fall, with 50% of the patients presenting in this season, while spring was the least common season for VKH presentation, with 12.5% of the patients presenting in this season. Our study suggests that the onset of VKH in Puerto Rico follows a seasonal pattern, with most cases occurring during the fall.为探讨伏格特-小柳-原田（Vogt–Koyanagi–Harada, VKH）病发病率与季节节律的相关性，本研究采用回顾性队列研究设计，纳入经确诊为VKH病且明确记录发病月份的患者。研究回顾性收集患者相关信息并录入数据库，按发病月份及季节进行统计分析，最终共纳入符合纳入标准的24例患者。分析结果显示，不同季节的VKH病发病率与预期分布存在统计学显著性差异（P=0.043）。其中秋季为VKH病最常见的发病季节，共有50%的患者在此季节发病；而春季则为最少见的发病季节，仅12.5%的患者在此季节发病。本研究表明，波多黎各地区VKH病的发病存在季节节律特征，大部分病例集中于秋季发作。