Early Developmental Deficits in the CF sheep model. Early Developmental Deficits in the CF sheep model

Cystic Fibrosis (CF) is associated with pathology in multiple tissues including the lung, digestive tract and reproductive system. Lung disease is primarily a post-natal event but other organs are affected before birth. Here we use the CF sheep model to investigate the initiation and progression of CF disease through gestation. Overall design: RNA-seq of sheep (ovis aries) tracheal epithelial tissue

囊性纤维化（Cystic Fibrosis, CF）可引发多组织病理损伤，受累组织涵盖肺脏、消化道与生殖系统。其中肺部病变主要为产后事件，而其他器官的病变则在产前即已发生。本研究利用CF绵羊模型，探究囊性纤维化疾病在整个妊娠周期内的起始与进展情况。实验整体设计：对绵羊（Ovis aries）的气管上皮组织开展RNA测序（RNA-seq）。