Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

To better understand the molecular changes in the aqueous humor (AH) content with glaucoma, we analyzed the microRNA (miRNA) profiles of AH samples from patients with Primary Open Angle Glaucoma (POAG) and Exfoliation Glaucoma (XFG) compared to non-glaucoma controls. This study profiled the expression of miRNAs in AH from patients with POAG (n = 12), XFG (n = 12), and cataract controls (n = 11).

为深入探究青光眼患者房水（aqueous humor，AH）成分的分子变化特征，本研究对比分析了原发性开角型青光眼（Primary Open Angle Glaucoma，POAG）、剥脱性青光眼（Exfoliation Glaucoma，XFG）患者与非青光眼对照者的房水样本微小核糖核酸（microRNA，miRNA）表达谱。本研究共纳入12例POAG患者、12例XFG患者及11例白内障对照者，对其房水miRNA的表达情况进行了表达谱分析。