Using natural variation Drosophila to discover previously unknown ER stress genes

To measure natural variation in ER stress transcriptional response in a subset of lines from the Drosophila Genetic Reference Panel Transcriptional response to Tunicamycin and control conditions was measured at 8 hours of exposure (20 lines) and 20 hours of exposure (8 lines).

为了检测果蝇遗传参考品系（Drosophila Genetic Reference Panel）中部分品系的内质网应激（ER stress）转录应答的自然变异，本研究对衣霉素（Tunicamycin）处理及对照条件下的转录应答进行了测定，分别在药物暴露8小时（20个品系）与20小时（8个品系）时完成检测。