Phenyliodine(III) Diacetate Mediated Oxidative Cyclization of 1‑Alkenoyl-1-carbamoyl Cycloalkanes: Access to Spiro-Fused Dihydrofuran-3(2H)‑ones

Facile and efficient synthesis of spiro-fused dihydrofuran-3­(2H)-ones was developed via phenyliodine­(III) diacetate (PIDA) mediated oxidative cyclization of 1-alkenoyl-1-carbamoyl cycloalkanes under very mild conditions.

本研究开发了一种简便高效的合成方法，通过二乙酸碘苯(III)（PIDA）介导的1-烯酰基-1-氨基甲酰基环烷烃的氧化环化反应，在极为温和的条件下合成螺环稠合二氢呋喃-3(2H)-酮类化合物。