Eprs1

Enables proline-tRNA ligase activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to type II interferon; and prolyl-tRNA aminoacylation. Located in plasma membrane. Part of GAIT complex and aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; axial skeleton; cerebellum; craniocervical region bone; and liver. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]

该基因激活脯氨酰-tRNA连接酶活性。参与多种生物过程，包括细胞对胰岛素刺激的反应；细胞对II型干扰素的反应；以及脯氨酰-tRNA的氨酰化。定位于质膜上。是GAIT复合体和氨酰-tRNA合成酶多酶复合体的一部分。在多个结构中表达，包括消化系统；中轴骨骼；小脑；颅颈区域骨骼；以及肝脏。该基因的人类同源基因与15型低髓鞘化白质营养不良有关。与人类EPRS1（谷氨酰-脯氨酰-tRNA合成酶1）同源。[由基因组资源联盟提供，2024年11月]