Effect of systemic adipsin overexpression on db/db mouse pancreatic islets. Effect of systemic adipsin overexpression on db/db mouse pancreatic islets

RNAseq of pancreatic islets of db/db mice treated with AAV- Adipsin vs AAV-GFP 4 weeks post AAV injection Overall design: Isolated pancreatic islets from db/db-GFP and db/db-Adipsin mice were used. Unbiased transcriptomic profiling was performed at 1 month post-transduction, when serum glucose levels were similar between both groups. RNA samples from pancreatic islets isolated from 4 db/db mice treated with AAV-GFP and 3 db/db mice treated with AAV-Adipsin were included in the analysis. Each mouse was a separate biological replicate.

携带脂素（Adipsin）的腺相关病毒（AAV-Adipsin）与携带绿色荧光蛋白（GFP）的腺相关病毒（AAV-GFP）处理的db/db小鼠胰岛的RNA测序（RNA-seq）数据集：病毒注射后4周
实验设计概述：从经AAV-GFP与AAV-Adipsin处理的db/db小鼠体内分离胰岛，于病毒转导后1个月开展无偏倚转录组分析，此时两组小鼠的血清葡萄糖水平相近。本分析纳入了4只AAV-GFP处理组db/db小鼠与3只AAV-Adipsin处理组db/db小鼠的胰岛RNA样本，每只小鼠均为独立生物学重复。