A Western-type Dietary Pattern Induces an Atherogenic Gene Expression Profile in the Coronary Arteries of the Ossabaw Pig

We investigated the effect of 2 food-based dietary patterns and statin therapy on the transcriptome of the left anterior descending coronary artery of the Ossabaw pig. Overall design: Thirty-two Ossabaw miniature pigs (16 boars, 16 gilts) were randomized using a 2x2 factorial design into four groups: Hearty Healthy diet (HHD); Heart Healthy diet + atorvastatin (HHD+S); Western diet (WD); and Western diet + atorvastatin (WD+S). Heart Healthy diet (high in unsaturated fat, unrefined grain, fruits/vegetables [HHD]) or Western diet (high in saturated fat, cholesterol, refined grain [WD]), with or without atorvastatin.

本研究探究了两种食物型膳食模式与他汀类药物治疗对奥萨巴马微型猪（Ossabaw miniature pig）左前降支冠状动脉转录组（transcriptome）的影响。实验设计概述：32只奥萨巴马微型猪（公猪、青年母猪各16只）采用2×2析因设计随机分为四组：健康心脏膳食组（HHD）、健康心脏膳食联合阿托伐他汀（atorvastatin）组（HHD+S）、西式膳食组（WD）以及西式膳食联合阿托伐他汀组（WD+S）。健康心脏膳食富含不饱和脂肪、未精制谷物与果蔬，西式膳食富含饱和脂肪、胆固醇与精制谷物，两组均分别接受阿托伐他汀干预或不接受干预。