Infant BF520 antibody sequencing

Infant BF520 was HIV infected at 3 months of age and subsequently developed a broadly-neutralizing antibody response. This study sequenced the variable regions of BF520's immunoglobulin genes (IgG, IgM, IgK, and IgL) at two timepoints: 1 week after birth (pre-infection) and 9 months after birth (6 months post-infection).

婴儿BF520于3月龄感染人类免疫缺陷病毒（HIV），随后产生了广谱中和抗体应答。本研究在两个时间点对BF520的免疫球蛋白基因（immunoglobulin genes）的可变区进行测序，涉及的免疫球蛋白亚型包括IgG、IgM、IgK及IgL，两个时间点分别为出生后1周（感染前）与出生后9个月（感染后6个月）。