Endothelial density analysis by age group of corneal donors in an eye bank in Paraná State, Brazil

Abstract Objective: To analyze the endothelial density of corneas donated for transplant in different age groups. Methods: The study evaluated 244 corneas from 122 male and female donors in Cascavel Eye Bank -PR from the analysis of medical records containing specular microscopy of the donors. Results: Most corneal donors were male (67.2%). The average donors age was 53.8 years, ranging from 5 to 70 years. The age group of 61 -70 years with the largest number of donations, corresponding to almost 41% and the average endothelial density was 2645 cells / mm² (ranging from 1897 to 4201 cells / mm²). In the first decade of life, mean endothelial density was 2923 cells mm²; in the second decade 2757 cells / mm²; in the third 2846 cells / mm²; in the fourth 2627 cells / mm²; in the fifth decade, 2830 cells / mm²; on the sixth 2605 cells / mm² and on the seventh decade of life 2570 cells / mm². Conclusion: This study demonstrated that the mean endothelial density of corneas donated for transplant of the first decade of life (2923 cells / mm²) when compared to the seventh decade alone (2570 cells / mm²) was reduced. In the evaluation from the second to the sixth decade, there was no pattern, sometimes there was an increase, sometimes a decrease in the average endothelial density.

摘要
研究目的：分析不同年龄组角膜移植供体的角膜内皮细胞密度（corneal endothelial density）。
研究方法：本研究对巴西巴拉那州卡斯卡韦尔眼库的122名男女供体的244枚角膜进行评估，通过分析包含供体角膜内皮显微镜检查（specular microscopy）结果的病历资料完成相关分析。
研究结果：本次研究的角膜供体中，男性占比达67.2%，为多数群体。供体平均年龄为53.8岁，年龄跨度为5至70岁。其中61~70岁年龄组的捐献数量最多，占比接近41%；该组平均角膜内皮细胞密度为2645个/mm²，范围为1897至4201个/mm²。生命第一个十年组的平均内皮细胞密度为2923个/mm²；第二个十年组为2757个/mm²；第三个十年组为2846个/mm²；第四个十年组为2627个/mm²；第五个十年组为2830个/mm²；第六个十年组为2605个/mm²；第七个十年组为2570个/mm²。
研究结论：本研究证实，与第七个十年组相比，生命第一个十年组的移植用角膜平均内皮细胞密度（2923个/mm²）有所降低。在对第二至第六个十年组的评估中，未观察到明确的变化规律，平均内皮细胞密度时而升高、时而降低。